Principal Scientist, Structure-Based Antibody Modeling
Employment Type: Full-Time
We are seeking a protein structure modeling expert to design industry-leading biotherapeutics as part of Pfizer's BioMedicine Design team in La Jolla, CA. The successful candidate will join project teams (primarily in oncology) to optimize protein-based therapeutic leads in early through late discovery, primarily using protein structure and molecular simulation. The candidate will also evaluate and create improved computational workflows. Other areas of opportunity may include data analysis data across programs to develop predictive models for pharmaceutical properties, and engineering improved protein scaffolds.
Works with project teams as a primary source of knowledge for structure-based computational analysis of protein biotherapeutic leads and provides optimized designs. Effectively communicates results and recommendations to colleagues with diverse scientific backgrounds. Evaluates/implements new or improved methods to increase throughput and/or accuracy of molecular modeling workflows. Analyzes data sets to discover relationships between protein structure and key pharmaceutical properties. Engineers improved general scaffolds for protein therapeutics.
BASIC QUALIFICATIONS PhD in biochemistry, chemistry, or a related field and 2-5 years of experience in the biopharmaceutical industry Use of molecular structure analysis to engineer binding between proteins and their binding partners. Expertise in one or more commonly used molecular modeling software packages. Programming in a Linux environment using a scripting language such as Perl or Python.
PREFERRED QUALIFICATIONS Working knowledge of antibody structure and function is a significant advantage. Working knowledge of bioinformatics tools and databases. Conducting research projects in a team setting, presenting results to scientists of varying technical backgrounds. Experience optimizing physical properties of proteins. Linux systems administration skills and knowledge of HPC environments. Experience with one or more of the following software suites: Schrodinger, Rosetta, Discovery Studio, FoldX. Experience integrating multiple scientific software toolkits to develop new analysis workflows usable by colleagues. Strong track record of publication in topics involving protein structure analysis.
Other Job Details: Eligible for Relocation Package Eligible for Employee Referral Bonus
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