Senior Scientist-Computational Biology/Bioinformatics

Employment Type

: Full-Time


: Scientific Research


Job Description:

This is where your legacy begins! The Leidos Innovations Center at Leidos currently has an opening for a Senior Scientist – Computational Biology to work in our San Diego, California office. We are seeking a broadly trained and highly motivated computational biologist to lead the development of analytical frameworks and computational methods targeting various applications in metagenomics, genetics/ epigenetics, and multi-omics. This is a highly dynamic and integrative environment in which talented and creative scientists can thrive working on a diverse array of multidisciplinary projects with a mission of solving some of our nation’s most demanding challenges. The group has an immediate need for someone with strong skills in NGS-derived data analysis and integration, including metagenomics, metatranscriptomics, metabolic pathway analysis, and predictive statistical modeling. The ideal candidate is motivated by modeling complex cellular systems and gaining mechanistic understanding based on large biological datasets. This is a unique opportunity to work at a collaborative, forward-thinking synthetic and systems biology team and help build groundbreaking solutions with direct applications in the field.

Roles and Responsibilities:

  • Lead computational efforts to characterize changes in multiple-omics profiles under different conditions using existing tools, and develop novel algorithms when required
  • Develop statistical and machine learning-based models to leverage new insight into biological systems from –omics data (e.g., genomics/metagenomics, transcriptomics/metatranscriptomics, metabolomics, epigenomics).
  • Contribute to the development of novel applications in support of government-funded efforts in the areas of synthetic and systems biology.
  • Effectively communicate research in team meetings, progress reports, peer-reviewed publications, and patents.
  • Quickly adapt to evolving research needs, rapidly acquire new scientific knowledge and stay informed on new technologies.
  • Work effectively as a member of an interdisciplinary team consisting of biologists, chemists, mathematicians, statisticians, and engineers. Lead Candidates should follow sound scientific practices and maintain effective documentation of activities and analyses.


To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below

  • A Ph.D. in Computational Biology, Bioinformatics, Biostatistics or related discipline with at least 5 years of technical experience (experience obtained during graduate or postdoctoral work can be counted towards total years of experience).
  • U.S. Citizen with the ability to obtain and maintain a Secret Security Clearance
  • Experience processing, analyzing and integrating multiple NGS-based data sets.
  • Linux scripting abilities and working knowledge of at least one program language (e.g., R, Pearl, Python, C++).
  • Strong background in statistics / machine learning applied to systems-level data types.
  • Strong background in Biology.
  • Highly motivated.
  • Strong independence in carrying out research tasks.
  • Collaborative with excellent written and verbal communication skills; ability to interact with people from diverse areas and disciplines.

Preferred Qualifications:

  • Integration of multiple -omics platform data
  • Network analysis
  • Development of predictive statistical models
  • Microbiome research experience
  • Synthetic Biology experience
  • Understanding of Molecular Biology / Genetics assays
  • Possess US government Security Clearance

Leidos is a global science and technology solutions leader working to solve the world’s

External Referral Bonus:


Potential for Telework:


Clearance Level Required:



Yes, 10% of the time

Scheduled Weekly Hours:




Requisition Category:


Job Family:

Research Scientist

Leidos is a Fortune 500® information technology, engineering, and science solutions and services leader working to solve the world’s toughest challenges in the defense, intelligence, homeland security, civil, and health markets. The company’s 38,000 employees support vital missions for government and commercial customers. Headquartered in Reston, Va., Leidos reported annual revenues of approximately $11.09 billion for the fiscal year ended January 3, 2020. For more information, visit

Pay and benefits are fundamental to any career decision. That's why we craft compensation packages that reflect the importance of the work we do for our customers. Employment benefits include competitive compensation, Health and Wellness programs, Income Protection, Paid Leave and Retirement. More details are available here.

Leidos will never ask you to provide payment-related information at any part of the employment application process. And Leidos will communicate with you only through emails that are sent from a email address. If you receive an email purporting to be from Leidos that asks for payment-related information or any other personal information, please report the email to

All qualified applicants will receive consideration for employment without regard to sex, race, ethnicity, age, national origin, citizenship, religion, physical or mental disability, medical condition, genetic information, pregnancy, family structure, marital status, ancestry, domestic partner status, sexual orientation, gender identity or expression, veteran or military status, or any other basis prohibited by law. Leidos will also consider for employment qualified applicants with criminal histories consistent with relevant laws.

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