Scientist/Senior Scientist, Computational Biology

Employment Type

: Full-Time


: Miscellaneous

JOB DESCRIPTION Instil Bio is a global clinical-stage biotechnology company focused on the development of novel immuno-oncology treatments called tumor infiltrating lymphocytes (TILs). TILs are naturally occurring immune cells that have the ability to identify and destroy cancer cells. Instil Bio is engineering TILs to harness and amplify their cancer fighting ability to treat of a broad range of solid tumor cancers. Instil Bio is located in Southern California with additional manufacturing and research facilities in Manchester U.K. We are seeking an enthusiastic, collaborative computational scientist with strong expertise in bioinformatics and cloud computing to join Instil Bios computational biology team. The successful candidate will play a pivotal role in advancing both preclinical- and clinical-stage programs by enabling the analysis and exploration of various complex datasets. In this role, the candidate will be directly reporting to the Computational Biology Team Lead. KEY JOB RESPONSIBILITIES * Develop, maintain, and apply state-of-the-art analysis strategies for extracting insights from high-throughput and high-content datasets, including those generated from bulk and single-cell TCR-Seq/RNA-Seq/ATAC-Seq, CITE-Seq, whole exome sequencing, spatial transcriptomics/proteomics, and high-dimensional flow cytometry, to inform and accelerate internal pipeline progression * Develop, deploy, and maintain data visualization applications, such as R Shiny apps, to enable the exploration of high-dimensional datasets by scientists, clinicians, and engineers * Acquire, optimize, and manage Azure cloud computing and storage resources to meet the computational needs of both preclinical- and clinical-stage programs * Design, build, and manage an internal cloud-based data repository that contains both internal and external datasets * Work cross-functionally with other departments such as research, translational medicine, analytical development, and IT teams to advance the development of autologous T cell therapy products * Further the company culture of scientific excellence, achievement, and compliance for the benefit of the companys stakeholders * Other duties as assigned ESSENTIAL JOB REQUIREMENTS * Ph.D. degree in computational biology or related disciplines with 0-3 years research experience * Experience scripting in Python, R and bash and the use of version control tools such as Git * Experience in managing AWS, Azure, or Google cloud computing resources * Experience in bioinformatic pipeline development and management * Experience in developing and maintaining data visualization applications such as R Shiny apps * Experience in analyzing single-cell RNA-Seq/TCR-Seq/ATAC-Seq, CITE-Seq, whole exome sequencing, spatial transcriptomics/proteomics, and high-dimensional flow cytometry datasets is preferred * Previous experience in cell therapy and/or immune-oncology field is preferred * Comfortable with learning new skills as needed * Experience working effectively in a fast-paced, team-based environment * Fluent verbal and written English language skills

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