Postdoctoral Fellow - Protein Sciences, Ciferri Lab

Employment Type

: Full-Time

Industry

: Miscellaneous



We are seeking a highly motivated postdoctoral fellow to join our cryo-EM group in the Department of Structural Biology, to investigate protein complexes involved in several disease areas, including Oncology, Infectious Disease, Cancer Immunology, and Neurobiology. At Genentech, our well-established cryo-EM group provides a unique opportunity for postdocs to join our team. This will include state-of-the-art technology for high-resolution data collection (2 Titan Krios equipped with Direct Detector, Energy Filter and Volta Phase Plate & Glacios/Talos Screening Microscope), a virtually unlimited computer cluster for data processing, and the opportunity to be fostered in one of the most productive and scientifically stimulating research environments. Who you are: * Candidates must have a PhD in structural biology, biochemistry, molecular biology, or a related field. * Expertise in protein purification, biophysical characterization, and structure determination of multi-protein complexes using X-ray crystallography and/or single-particle cryo-EM is required, as evidenced by a strong record of first-author publications in top peer-reviewed journals. * Experience in protein engineering along with biophysical characterization methods for protein-protein interactions, such as surface-plasmon resonance (SPR) or bio-layer interferometry (BLI), will be considered a plus. * Highly motivated and detail-oriented researcher, driven to solve complex scientific problems, and able to work both independently and in a collaborative environment. * Strong oral and written communication skills are required. More Information about the Genentech Postdoctoral Program: http://www.gene.com/careers/academic-programs/postdocs More information about the Ciferri Lab: https://www.gene.com/scientists/our-scientists/claudio-ciferri Relevant Publications: Kschonsak M. et al. (2021). Structures Of HCMV Trimer Reveal The Basis For Receptor Recognition And Cell Entry. Cell, in Press Kschonsak M. et al. (2020). Structure of the sodium leak channel NALCN Nature 2020 Jul 22. doi: 10.1038/s41586-020-2570-8 Kumar N. et al. (2020) Structure of the Secretory Immunoglobulin A Core. Science 367(6481):1008-1014. DOI: 10.1126/science.aaz5807 Martinez-Martin et al. (2018). An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor. Cell. 2018 Aug 23;174(5):1158-1171 #L1-SN1 #postdoc

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