Senior Research Associate/Principal Research Associate, Genomics

Employment Type

: Full-Time


: Miscellaneous

Who we are: Calico is a research and development company whose mission is to harness advanced technologies to increase our understanding of the biology that controls lifespan. We will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Executing on this mission will require an unprecedented level of interdisciplinary effort and a long-term focus for which funding is already in place. Position description: Calico is seeking to fill a Research Associate position in our Genomics Core Lab. The successful candidate will work as part of a multi-disciplinary team, assisting Calico's scientists with execution of their basic aging research experiments by providing sequencing expertise and service. The well-qualified candidate has a solid grasp of molecular biology and hands on experience with cutting edge Genomics technology. Position requirements: * BS or MS degree in Biology, Molecular Biology, Biochemistry, Chemistry or related discipline (PhD not expected) with a minimum of 4 years relevant experience * Prepare of DNA/RNA libraries using automated liquid handling platforms, run the libraries on an Illumina NovaSeq, and perform initial QC of the data * Operate and troubleshoot laboratory robotics (Agilent Bravo, Tecan, Hamilton, Beckman, Echo, etc.) * Collaborate with the Automation Team to migrate new methods onto the liquid handlers * Collaborate with the software engineering team to assist them in configuring a LIMS for our Genomics Lab * Must have hands on experience with various nucleic acid sample quantitation methods (Fragment Analyzer, Bioanalyzer, Qubit, qPCR, etc.) * Possess excellent communication skills with an ability to work as part of a high-performing team and with the broader Calico community * Be flexible and able to respond quickly to shifting priorities; handle multiple projects simultaneously * Must be detail-oriented and organized; must possess the initiative to organize your week efficiently * Mentor other lab members, and train members of the broader Calico community on NGS methods Nice to have: * Working knowledge of library prep and sequencing instrumentation (Illumina, Pacific Biosciences, or other platforms) * Hands-on experience with DNA and RNA extraction methods from cell culture and tissue * Experience with NanoString hybridization methods * Familiarity with single cell sequencing approaches * Knowledge of basic statistics and genomic data analysis tools: some Python or R coding ability is desirable but not required

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