Scientist II, Protein Engineering

Employment Type

: Full-Time


: Miscellaneous

Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas! Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at Xyphos Biosciences, an affiliate of Astellas Pharma Inc. is developing a novel adoptive cell therapy technology platform and building a pipeline of innovative products. We are a rapidly growing team of research and scientific professionals, passionate about turning science and innovation into medical solutions through our cell therapy technology platform. Through our diversity, scientific knowledge, professional rigor and focus on innovation, we are merging our technology with the Astellas drug development expertise to unlock cures to many therapies. Join our team of committed, enthusiastic professionals devoted to making the most effective, life-saving cell therapy products in the world. Astellas is announcing a Scientist II, Protein Engineering opportunity at their Xyphos site in South San Francisco, CA. Purpose: The primary focus of the Scientist II in Protein Engineering is to join our efforts in the discovery and engineering of novel antibodies/MicAbodies for Xyphos' convertibleCAR cellular therapy platform. This includes developing antibody discovery strategies and technologies, as well as supporting construct design and screening of different antibody formats. This position will work primarily in a laboratory setting with R&D teams. Essential Job Responsibilities: * Lead and collaborate internally (Astellas) and externally (CROs) on antibody discovery using hybridoma/B-cell and/or directed evolution (phage/yeast display) approaches against soluble or complex membrane protein targets for immuno-oncology * Design and execute efficient antibody screening cascades and experiments for projects at different stages * Understand the biology behind targets, design and generate immunogens, and explore different antibody formats including bispecific, multispecific antibodies and antibody-fusions * Integrate data from sequences, binding assays, and functional characterization experiments to support a comprehensive data package for antibody hit/lead selection * Evaluate new technologies, instrumentation, and assays to implement and improve in-house antibody discovery/engineering platforms * Manage protein engineering database with other members in the protein engineering team: Standardizes processes, documentation, reagent inventories and captures data to record and share information with Xyphos scientific research team * Excellent communication skills with a solid ability to articulate experimental plans, present research findings in meetings, works effectively in a cross-functional team, and collaborate with other members of Astellas R&D teams Qualifications: Required * Ph.D. with 3+ years, MS with 7 + years or a BS with 10 + years of related industry and/or post-doctoral experience in antibody discovery, protein biochemistry/engineering and molecular biology * Demonstrated experience successfully executing on de novo antibody discovery through hybridoma/B-cell cloning or directed evolution (phage/yeast display) approaches * Proficiency in antibody binding, epitope binning and mapping, and functional assays using ELISA, Octet/Biacore and/or flow cytometry * Strong understanding of antibody structure/sequence and function relationship * Extensive experience in the molecular biology and purification techniques essential for antibody engineering/reformatting/bispecific/multispecific/single domain antibodies and construct design/generation * Willingness to learn and enthusiasm to be part of the development of a cutting-edge therapy platform * Excellent organizational, time management, problem-solving and communication and interpersonal skills * Ability to work independently and ability to effectively collaborate with other teams; collegiality is a critical attribute * Strong work ethic with a dedicated mindset of proactively identifying and productively filling gaps * Strong team-oriented mentality exemplified by willingness to take on tasks and responsibilities as needed to facilitate advancement of a wide variety of programs in a dynamic, start-up like environment Preferred * Experience with CRO project management * Experience with Cytiva Akta FPLC system / any HPLC system / biophysical techniques * Experience with structural biology and modeling techniques * Experience with cell binding and in vitro cell / signaling assays Benefits: * Medical, Dental and Vision Insurance * Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down * 401(k) match and annual company contribution * Company paid life insurance * Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions * Long Term Incentive Plan for eligible positions * Referral bonus program Astellas is committed to equality of opportunity in all aspects of employment. EOE including Disability/Protected Veterans Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled

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